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How to use Turbohaler
The number of studies investigating characteristics of the Turbuhaler® exceeds research on any other dry powder inhaler. It is one of the DPIs with a relatively high intrinsic resistance. Therefore formation of the fine particle fraction highly depends on the flow achieved within the system. Since highly correlates with particle size interindividual variability of efficacy must be anticipated.
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With a reasonably high inspiratory flow of 60 l/min a large fraction of very small particles is generated (in average 2.5 µm). However in comparison to a low resistance DPI the same inspiratory force yields a flow of 60 l/min through the Aerolizer® and of 28 l/min through the Turbuhaler®. Under these conditions the Aerolizer® emits 82% of the metered dose with an average particle size of 4.26 µm while the Turbuhaler® releases 58% of the metered dose with an average particle size of 5.5 µm.
The Turbuhaler® is approved for the drugs budesonide (Pulmicort®, Spirocort®), formoterol (Oxis®), terbutaline (Aerodurâ®, Bricanyl®) and a combination of budesonide plus formoterol (Symbicort®).
This section contains a list of things you should do (DOs) and things you shouldn’t do (DON’Ts) when using the Turbohaler. This list only covers items known from practice to be the most important and most likely to be forgotten or performed incorrectly by patients; this information is in addition to the prescribing and other information provided with the Turbohaler.